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-synuclein, that's a main component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which happens to be an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) tension, advise that dysfunction of the intracellular proteinase techniques, for example ubiquitin-proteasome technique or lysosomal technique, which removes needless
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